Introducing
Cissuslean®
A standardized full-spectrum Cissus quadrangularis extract with naturally occurring polyphenols, flavonoids, glycosides and saponins.
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The Ingredient
Introducing Cissuslean®
Cissuslean® is a clinically studied, standardized extract of Cissus quadrangularis, a succulent medicinal vine native to India and traditionally associated with bone and joint health. Its full-spectrum bioactive profile includes resveratrol, piceatannol, quercetin, isorhamnetin, luteolin, myricetin, quercitrin, genistein, daidzein and diosgenin.
Scientific studies have explored how Cissuslean® supports healthy body composition, lipid metabolism, inflammatory balance and joint function. Manufactured by Star Hi Herbs, it is designed for dietary supplements and functional nutrition products targeting healthy weight, active ageing and mobility.
Quality & Certifications
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A science-first ingredient story
How Cissuslean® Works
Explore how Cissuslean® may influence adipogenesis, lipid metabolism, inflammatory pathways and joint-tissue protection.
Explore the Mechanism of ActionClinical Research
Review human clinical findings related to body composition, waist and hip measurements, abdominal fat and knee joint function.
View Clinical ResearchIntellectual Property
Cissuslean® is the subject of patent applications filed in India, through the PCT route and in the United States.
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View Grades & SpecificationsFull-Spectrum Profile
Naturally Occurring Bioactives
Cissuslean® preserves a full complement of polyphenols, flavonoids, glycosides and saponins native to Cissus quadrangularis.
Resveratrol
A polyphenol studied for antioxidant and metabolic-supporting properties.
Piceatannol
A naturally occurring stilbene linked to antioxidant activity and cellular metabolic pathways.
Quercetin
A flavonoid studied for antioxidant activity and balanced inflammatory response.
Isorhamnetin
A methylated flavonoid investigated for inflammatory and joint-related pathways.
Myricetin
A plant flavonoid associated with antioxidant and metabolic activity.
Quercitrin
A naturally occurring quercetin glycoside in the full-spectrum flavonoid profile.
Luteolin
A flavonoid studied for antioxidant and inflammation-modulating activity.
Kaempferol Glycoside
3-O-Rhamnopyranosylkaempferol, a naturally occurring kaempferol glycoside.
Genistein & Daidzein
Naturally occurring glycosides associated with bone and metabolic health.
Diosgenin
A plant saponin studied for metabolic and inflammatory pathways.
Health Benefits
Made for weight, joints and active ageing
A single ingredient positioned across two of the fastest-growing categories in dietary supplements — healthy weight and joint mobility.
Supports Healthy Body Composition
Helps support reductions in body fat and abdominal measurements when combined with an appropriate lifestyle.
Supports Healthy Weight Management
Studied for its effects on lipid accumulation, adipogenesis and metabolic biomarkers.
Promotes Joint Comfort
Clinically evaluated for improvements in pain, stiffness and physical function among adults with knee osteoarthritis.
Supports Mobility & Physical Function
Helps maintain joint movement and daily activity performance.
Supports Healthy Lipid Metabolism
Human research reported favourable changes in total, LDL, HDL cholesterol, triglycerides and VLDL.
Provides Antioxidant Support
Contains a broad spectrum of naturally occurring polyphenols and flavonoids.
Human Clinical Evidence
Clinical Proof, in Two Trials
Trial 1 · Body Composition
12-Week Weight-Management Study
In a 12-week trial involving 100 overweight or obese adults, participants receiving Cissuslean® demonstrated statistically significant reductions in body fat mass and body fat percentage, alongside favourable changes in adiponectin, leptin and lipid profile. No serious adverse events were reported.
Trial 2 · Joint Function
84-Day Knee Osteoarthritis Study
A separate 84-day study evaluated Cissuslean® at 300 mg/day in adults with knee osteoarthritis. The Cissuslean® group achieved meaningful improvements in WOMAC, VAS pain, stiffness, physical function and inflammatory markers.
Human clinical study manuscripts were identified in the supplied materials as being under preparation. Final website language should be checked against approved manuscripts before publication.
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Product Presentation
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Parent Company
Manufactured by Star Hi Herbs
Established in 2004, Star Hi Herbs Pvt. Ltd. is an Indian manufacturer and global exporter of standardized herbal extracts and nutraceutical ingredients. Its ingredients serve the dietary supplement, nutraceutical, pharmaceutical, food and cosmetic industries.
Star Hi Herbs combines botanical knowledge, research, standardized manufacturing and quality-control systems to develop differentiated ingredients for customers worldwide.
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Looking for a clinically studied Cissus quadrangularis extract for a weight-management, joint-health or active-ageing formulation? Request a sample, commercial quotation or technical discussion.
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